Reach Us +441904929220

Abstract

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 5-METHYLPYRAZINE-2- CARBOHYDRAZIDE DERIVATIVES

Here an attempt has been made to synthesize fourteen 5-methylpyrazine-2-carbohydrazide derivatives. The synthesized derivatives were assessed for their in-vitro anti-bacterial activity and minimum inhibitory concentration (MIC) against Gram-positive strains (Staphylococcus aureus and Bacillus subtilis) and Gram-negative strains (Salmonella typhi and Escherichia coli). During the present work, 5-methylpyrazinoic acid was esterified with ethanol to get ethylpyrazinoate and it refluxed with hydrazine hydrate to yield the 5-methylpyrazinoic acid hydrazide. The obtained acid hydrazide was then condensed with various substituted aromatic aldehydes to yield various 5-methylpyrazine-2- carbohydrazide derivatives. The structures of newly synthesized compounds so obtained were confirmed by using IR, 1HNMR, MS spectral data. All compounds gave satisfactory elemental analyses. The compounds PM 8-10, (i.e. 2,3 and 4- nitro benzaldehyde derivatives respectively) showed promising activity amongst the compounds tested against both the Gram-positive and Gram-negative strains tested. .


Author(s): MINIYAR P. B. AND MAKHIJA S. J.

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
Flyer image

Abstracted/Indexed in

  • Chemical Abstracts Service (CAS)
  • Index Copernicus
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • MIAR
  • ResearchGate
  • University Grants Commission
  • Secret Search Engine Labs