The effect of the extract of Cyperus esculentus on the changes in sperm count, activity, morphology and testicular histology induces by lead acetate was studied.18 adult male rats were randomly divided into three experimental groups. Group 1 (control) were given clean drinking water and rat chow, group 2 were given intraperitoneally injection 8mg/kg body weight + water + rat chow. Group 3 were given intraperitoneally injection 8mg/kg body weight + water with extract of Cyperus esculentu+ rat cho . The results show a destruction in the testicular histology, decreased sperm count, activity and morphology of Group 2 administered with lead acetate only, which was statistically significant (P<0.05), and there was also a dose-dependent improvement in the parameters studied in the Group 3 given extract of Cyperus esculentus. This shows that the extract of Cyperus esculentus has a regenerative effect on the destroyed testicular histology induced by lead acetate.