Tramadol HCl was microencapsulated with Ethylcellulose using multiple emulsion solvent evaporation method. A 32 factorial design employed to study the effect of drug: polymer ratio and volume of External phase (1% PVA) on % yield, % encapsulation efficiency, particle size, % drug release rate. The drug: polymer ratio and volume of continuous phase were significant effect on % yield, % entrapment efficiency, particle size, % drug release rate. % drug release was Biphasic system first initially bursting effect and finally sustained. Higher Percentage yield (77.4%) and Higher Percentage Encapsulation Efficiency(31.1%) were observed in Batch EC3. All the microspheres were spherical in nature its surface was smooth observed in SEM report.
All Published work is licensed under a Creative Commons Attribution 4.0 International License
Copyright © 2019 All rights reserved. iMedPub LTD Last revised : October 15, 2019