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Abstract

Pharmacotherapeutic Principles of Ungual Drug Delivery System

Ungual drug delivery (UDD) system bestows upon with the human nail as a hydrophilic barrier which can be used as a novel pathway to drugs used for therapy of nail disorders and also indications which cause those abnormalities. The common aberrations include onychomycosis, nail psoriasis, yellow nail syndrome, paronychia, etc for which UDD can be thought of. The basic requirement of any pathological condition is a drug in its appropriate dosage form. Although the nail barrier has a physiology which restricts drug absorption but certain physical and chemical modifications can be done to corroborate the drug delivery. Nail lacquers, polishes, varnishes and other forms of antifungal drugs are employed to accentuate drug action at sites of mechanical distortion or mycological infections. The electrochemical techniques and surgical procedures required are understood to enhance optimal drug therapy. The present paper studies the various ungual disorders and ways to treat them using the novel ungual delivery system.


Author(s): Surabhi Khanna, Ritesh Bajaj, Bhawna Khurana & Kinshuk Srivastava

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