Abstract

Marine Halophyte: An Inviolated and Promising Source of Novel Lead Compounds against Deadly Diseases like Dengue and Breast Cancer

The present study was started with an intention to unveil the potentials of marine halophyte Salicornia europaea abundant in south east coast of Tamilnadu. To study the metabolite, profile the shade dried biomass of the halophyte was extracted with methanol and ethyl acetate and the fractions showed 29 and 32 lead molecules respectively. The drug targets against dengue virus protein NS5 and Estrogen Receptor (ER) protein for breast cancer were retrieved from PDB and docked with selective lead molecules of solvent fractions with the help of Hex 6.3. E-min/E-max values for the tested lead molecules against the corresponding drug targets were calculated. Significant results have been obtained and suggest that this unexploited halophyte could be exploited to harvest promising lead molecules.


Author(s):

Samuel P, Vijayakumar J, Sudarmani DNP, Rajeswari P, Amirtharaj K and Deenathayalan R



Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+

Recommended Conferences

  • International Conference on Drug Discovery, Designing and Development
    June 27-28, 2018 Vancouver, British Columbia, Canada
  • World Drug Delivery Summit
    September 24-25, 2018 (10 Plenary Forums - 1Event) Chicago, Illinois, USA
  • International Conference on Pharmaceutical Chemistry
    October 29-31, 2018 Brussels, Belgium
Flyer image

Abstracted/Indexed in

  • Chemical Abstracts Service (CAS)
  • Index Copernicus
  • Google Scholar
  • Genamics JournalSeek
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • MIAR
  • ResearchGate
  • University Grants Commission