Reach Us +441904929220

Abstract

ISOLATION, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF CHARANTIN FROM MOMORDICA CHARANTIA LINN. FRUIT

Momordica Charantia (Cucurbitaceae) is commonly known as bitter guard in English and karela in Hindi. The fruit has claimed to contain charantin, steroidal saponin, momordicosides, carbohydrate, mineral matters, ascorbic acid, alkaloids, glucoside, etc. Earlier claim shows that the plant used as stomachic, carminative, tonic, antipyretic, antidiabetic, in rheumatoid arthritis and gout. The present investigation was carried out to isolate, purify and characterize Charantin from fruit of Momordica Charantia Linn. The isolated charantin was further characterized with the help of Ultraviolet Spectroscopy, Thin Layer Chromatography, Fourier Transform Infra Red Spectroscopy, Mass Spectroscopy, Proton- Nuclear Magnetic Resonance Spectroscopy confirmed the identification. The antibacterial activity of charantin was tested by using Agar Diffusion (Cup Plate) method. The minimum inhibitory concentration (MIC) of crude extracts were determined for various organism which was 0.2 mg/ml. The present studies confirm better antimicrobial activity of Charantin when compared with standard, against bacterial species such as gram positive (Bacillus subtilis), gram negative (Pseudomonas aeruginosa) and fungal strains (Saccharomyces cerevisiae).


Author(s): Subhashchandra Patel , Tushar Patel , Kaushal Parmar, Yagnesh Bhatt, Yogesh Patel , Dr. N.M. Patel

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
Flyer image

Abstracted/Indexed in

  • Chemical Abstracts Service (CAS)
  • Index Copernicus
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • MIAR
  • ResearchGate
  • University Grants Commission
  • Secret Search Engine Labs