The leaf extracts of Basella alba Linn.var. alba were investigated for In-vitro anti-inflammatory activity by human red blood cell membrane stabilization method (HRBC). The increased use of natural product in the pharmaceutical industry has led to an increase in demand for screening for cost effective, nontoxic bioactive compounds in medicinal plants. Now a day’s many researchers interest is to search medicinal plants with potent therapeutic activity which may lead to the discovery of new therapeutic agent. In this work the methanolic extract of Basella alba (M.E.B.A.) and aqueous extract of Basella alba (A.E.B.A.) were studied for its in-vitro antiinflammatory activities. The potency of the extracts was compared with standard Diclofenac sodium (50 and 100 @g/ml). The aqueous extract showed the most significant membrane stabilizing action on human red blood cell membrane.