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Abstract

Invitro and Invivo anticancer activity of Ethanolic extract of Canthium Parviflorum Lam on DLA and Hela cell lines

Background: Wild Jessamine, Canthium Parviflorum Lam, ( fam: Rubiaceae) is traditionally used for snake bite in some villages in shimoga district of Karnataka. Canthium Species are used in the treatment of tumor, cough, astringent and anthlementic. Objective: In this study, invitro and invivo anticancer activity of crude ethanolic extracts from the leaves of Canthium Parviflorum Lam was investigated Method: The invitro anticancer activity was measured by MTT assay and Exclusion method. The invivo studies was determined in mice using Dalton’s lymphoma ascetic (DLA) cells. Results: The ethanolic extacts of C.Parviflorum greatly inhibited DLA and Hela cell growth with IC50 Of 61.24μg/ml and 43.15μg/ml respectively. A significant increase in the life span and a decrease in the cancer cell number & tumour weight were noted in the tumor induced mice after treatment with Canthium Parviflorum Lam. Conclusion: Anticancer activity of Canthium Parviflorum was may be due to flavonoid present in the plant . Further studies are also in process to evaluate the most potent fraction of the plant and to isolate the constituents of the fraction


Author(s): Purushoth Prabhu.T, Panneerselvam.P, Selvakumari.S , Sivaraman.D

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