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Abstract

In Vitro Anti-Inflammatory and Antiarthritic Activity of Pergularia daemia Leaves and Roots

The In Vitro anti-inflammatory and antiarthritic activity of leaves and roots of Pergularia daemia by membrane stabilization assay, protein denaturation assay and albumin denaturation assay was performed. Three different concentrations of ethanolic extract of leaves and roots were used in this study and the reaction was observed in dose dependent manner. In membrane stabilization assay, the maximum % stabilization was observed in ethanolic extract of leaves (54.55%) at 300 μg/ml than roots (45.55%) and it showed significant activity than the standard drug diclofenac sodium (72.73%) at 100 μg/ml. Similarly, in the protein denaturation assay, the ethanolic extract of roots showed maximum % of inhibition (58.89%) at 300 μg/ml than the leaves (53.33%). The roots showed significant activity than the standard drug diclofenac sodium (74.44%) at 100 μg/ml. Moreover, in the albumin denaturation assay, the ethanolic extract of the leaves of P. daemia showed maximum % of inhibition (58.62%) at 300 μg/ml than roots (53.33%) and also showed significant activity than standard drug diclofenac sodium (73.56%) at 100 μg/ml. Thus we concluded that the ethanolic extract of the leaves of Pergularia daemia possess strong anti-inflammatory and antiarthritic activity than the roots.


Author(s):

Iffath Hina M and Caroline Rose J



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