Scoparia dulcis Linn, belongs to the family Scrophulariaceae and have speculated Medicinal properties. In this present investigation, the antioxidant and hepatoprotective activity of the aqueous extracts of Scoparia dulcis was evaluated against N-nitrosodiethylamine (DEN) induced liver cirrhosis in experimental rats. In group III hepatotoxicity induced animals, an oral dose of 500 mg/kg, of the aqueous extracts of Scoparia dulcis exhibited a significant (P<0.01) decrease in marker enzyme levels and increased levels of antioxidant enzymes. There is a significant reduction in the LPO levels in the group III extract treated animals against DEN induced liver toxicity. From the results of our investigation, we concluded that, the aqueous extract of Scoparia dulcis L showed significant antioxidant defence mechanism and hepatoprotective activity.