Multiple sclerosis (MS) is a polygenic disease driven by dysregulation of the immune system leading to an autoimmune response against antigens of cerebral white matter tissue. Experimental autoimmune encephalomyelitis (EAE) is a widely accepted model in vivo for the development of new therapy for the treatment of MS. There are different types of rodent EAE model and immunized with different epitopes for the analysis of gene expression and cytokines response in inflammation, demyelination and degeneration of neurons. The present review aimed to effect of gene and cytokines expression and therapeutic regimen in MS.
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