The aim of the study was to design, optimize and evaluate transdermal glycerogelatin in situ film containing Calotropis gigantea leaves extract for the treatment of Arthritis. Skin is considered as an important route of administration for both local and systemic effects. Topical film forming systems are developing drug delivery system ment for topical application to the skin, which adhere to the body, forming a thin transparent elastic film which provide delivery of active ingredient to the body tissue. The formulation was optimized by mixture design (design expert software, version 11.03) with glycerin, gelatin, water as the factors and spreadability, elasticity, drying time, and tensile strength as the responses. Calotropis gigantea having significant anti-inflammatory potential and its ethanolic extract was incorporated into the optimized formula of glycerogelatin in situ film. The optimized formula contained 1.5% of drug extract and showed a drug release of 79% at 8th hour, and 96% in 24 hour time period.
Reshma Thampy and AJ Chacko*
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