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Abstract

FORMULATION AND OPTIMIZATION OF SUSTAINED RELEASE MATRIX TABLETS OF DICLOFENAC SODIUM USING PECTIN AS RELEASE MODIFIER

Purpose: In the present investigation, an attempt was made to increase therapeutic effectiveness, reduction in dosing frequency and thus improving patient compliance, by developing sustained release matrix tablets of Diclofenac sodium using pectin as release modifier.

Method: Six batches of sustained release matrix tablets of Diclofenac sodium were prepared by using different drug: polymer ratios viz. 1:1, 1:1.5, 1:2, 1:2.5, 1:3, and 1:3.5 for pectin. Pectin was used as matrix forming material, while microcrystalline cellulose was used as filler to maintain the tablet weight. The tablets were analyzed to determine their hardness, friability, weight variation, and an In-vitro release of drug was performed in phosphate buffer saline pH 7.4 for twenty four hours. Swelling study was also carried out to study dispersibility of pectin at different concentrations.

Results: All the physical characters of fabricated tablet were within acceptable limits. As the concentration of pectin increases, swelling index also increased. Table showed better release retardant in a specific concentration range.

Conclusions: It is clear through the dissolution studies that the release profile of Diclofenac sodium from matrix tablets prepared using pectin was retarded approximately 24 h. Thus pectin stands as a potential candidate for sustained release formulation.


Author(s): Malviya Rishabha, Srivastava Pranati, Bansal Mayank, Sharma Pramod Kumar

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