The present study was designed to formulate and evaluate different formulae of topical gel containing Clarithromycin for treatment of skin infections. The gel was formulated by using different polymers with different concentrations of HPMC K4M, carbopol 934 and sodium alginate. Twelve different formulae were prepared and characterized physically in terms of color, pH, homogeneity, spreadability, drug content, viscosity and invitro drug release. Clarithromycin -excipients compatibility studies were confirmed by carrying out FTIR studies. In-vitro drug release study through dialysis membrane using a modified Franz diffusion cell was performed. The results of in-vitro release studies showed that the highest values was from F9 (90.6% of drug released after 12hrs). Also F9 formulation revealed that the viscosity was very less compared to other formulations and it was concluded that sodium alginate gel (F9) containing Clarithromycin showed good consistency, spreadability and homogeneity. Moreover, the stability study results of F9 formulation revealed no significant difference between before and after storage for selected formula.