The present study aimed to formulate orodispersible tablets of memantine hydrochloride to increase its bioavailability. Orodispersible tablets were prepared by direct compression technique using sublimation approach. The prepared powder mixtures were subjected to both pre and post compression evaluation parameters including; micromeritics properties, tablet hardness, friability, wetting time, disintegration time and in vitro drug release. The results of micromeritics studies revealed that all formulations were of acceptable to good flowability. Tablet hardness and friability indicated good mechanical strength. The F9 formulation which is having high concentration of camphor was given promising results for tablet disintegration, wetting time and gives faster dissolution rate. This increase in the dissolution rate may be due to the presence of crospovidone which is used as a superdisintegrant. This work is helped in understanding the effect of formulation processing variables especially the subliming agent on the drug release profile.
Jeevitha M and Pandey VP
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