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Abstract

EVALUATION OF SUB-ACUTE TOXICITY PROFILE OF FIXED DOSE COMBINATION OF MEROPENEM AND SULBACTAM IN WISTAR RATS

The present study investigated safety/toxicity profile of fixed dose combination of Meropenem and Sulbactam injection in rats at three dose levels, ranging from asymptomatic to high dose. The doses injected were 100mg/kg, 200 mg/kg and 400 mg/kg. Various physiological, hematological and biochemical parameters were studied. Outcomes of the present study suggested that no significant change in physiological, biochemical as well as hematological parameters were observed. No mortality was observed in any of the treatment groups. It was concluded that Meropenem and Sulbactam combination exerted no toxicity and is a safe medicine.


Author(s): Sehgal Rajesh, Purohit Harsh, Arora Parmjit

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