In the present investigation the Petroleum ether (60- 80), chloroform, alcohol and aqueous extracts of Erythrina mysorensis Gamb, stem bark were investigated for antibacterial and antifungal activities. Chloroform and ethanol extracts possessed antibacterial activity in a concentration dependent manner against the gram +ve and gram –ve organisms. The effects of these extracts are compared to standard drugs, benzyl penicillin and streptomycin. Both the ethanol and aqueous extracts possessed antifungal activity in a concentration dependent manner against the fungus. The effects of these extracts are compared to standard drug gentamycin. The phytochemical screening of the extracts revealed the presence of secondary metabolites like glycosides, alkaloids, flavonoids, tannins, triterpenoids and saponins etc.