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Abstract

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION PROPERTY OF GRISEOFULVIN BY NANOCRYSTALLIZATION

The aim of this study was to develop the formulation of griseofulvin by nanocrystallization for the enhancement of solubility and dissolution property of drug. In the present study the area of interest are drugs belonging to class II of BCS classification. Nanocrystal is a new carrier free colloidal drug delivery system with particle size ranging from 100-1000 nm, and is considered as a viable drug delivery strategy to develop the poorly soluble drugs. In the present work an attempt was made to enhance bioavailability of Griseofulvin by nanocrystallization technique. The drug nanocrystals (NC) were prepared by emulsion solvent diffusion method. Two different solvents such as acetone and ethanol and two different stabilizers such as β-cyclodextrin and sodium lauryl sulphite (SLS) were evaluated in the process. All formulations were in the size range of 600-900nm and showed marked improvement in dissolution velocity when compared to pure drug (3-4 μm), thus greater bioavailability. Short term stability studies were carried out as per ICH guidelines and from the stability studies it was conformed that nanocrystal formulation of griseofulvin remain stable at ambient temperature then at elevated temperature and humidity condition. The diffractograms confirms that the method for preparing nanocrystals does not interfere with griseofulvin state as diffraction patterns are conserved for the formulated nanocrystal formulations. Finally it was concluded that formulating poorly water soluble drugs in the form of drug NC would be a promising approach in delivery of class II drugs by oral route in much efficacious way.


Author(s): Phanchaxari M Dandagi , Sumit Kaushik, Shaktish Telsang

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