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Abstract

Effect of Coccinia grandis on ammonium chloride and ethylene glycol induced urolithiasis in rats

The hydroalcoholic leaf extract of coccinia grandis was evaluated for its antiurolithiatic property against ammonium chloride and ethylene glycol induced urolithiasis in rats. Albino rats were induced lithiasis by administered with 1% ethylene glycol and ammonium chloride in drinking water for 28 days .Lithiatic animals showed high urinary calcium,phosphate ,oxalate, ,uric acid and creatinine. In other groups after the initial 15 days administration of ethylene glycol with ammonium chloride, the hydroalcoholic leaf extract of coccinia grandis (200mg or 400mg/kg body weight per oral) was administered with ethylene glycol and ammonium chloride from 15 days to 28 days. Plant extracts reduced urinary calcium ,phosphate, oxalate ,uric acid and creatinine .Plant extract by increasing the urine volume, reduce the tendency of crystallization. Histopathological study showed the lithiatic confirmation of micro crystals deposition in kidney section of ethylene glycol treated animals. Plant extract treatment reduced this crystals deposition .These findings confirmed the antiurolithiatic activity of hydroalcoholic leaf extract of coccinia grandis against ethylene glycol and ammonium chloride induced urolithiasis


Author(s): M. Manimala, W. Clement Atlee, A. A. Sheik Mohamed, Purushoth Prabhu T

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