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Abstract

EFFECT OF â -CYCLODEXTRIN ON PHYSICAL STABILITY OF NIMESULIDE SUSPENSION

Stability of disperse systems is always a challenging task for formulator and thus assurance of physical stability of such system by proper evaluation is mandatory. The efficiency of suspension is related to the efficient dispersion of drug particles in the vehicle at the time of dosing. Patient compliance is difficult to assure, if redispersibility is poor. Present study shows the effect of ? -cyclodextrin on physical stability of nimesulide suspension which also includes formulation and evaluation. These formulations were evaluated for sedimentation volume, redispersibility, pH measurement, viscosity measurement, particle size, and drug content estimation at various time intervals for 3 months. It also includes DSC studies in order to assess the complexation with ? -cyclodextrin. Outcomes of all quality parameters suggest that nimesulide suspension formulations F4 i.e. drug: â -cyclodextrin with 1:1.5 ratio was optimum.


Author(s): Panda Madhulita, Patro Ganesh, Malpani Amol, Majji Sunil, Rao Bhanoji M. E.

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