Reach Us +441904929220
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Development and Validation of RP - HPLC method for the estimation of Telmisartan in bulk and tablet dosage Form

A simple, precise, rapid, and reproducible RP -HPLC method was developed and validated for the determination of Telmisartan in Pharmaceutical dosage form. Separation was achieved under optimized chromatographic condition on a Zorbax-SB-18 ;(ODS) column (150 X 4.6 mm i.d., particle size 3.5μ).The mobile phase consisted of Pentane sulphonic acid sodium salt mono hydrate, add 1ml of Perchloric acid and adjust the pH-2.7±0.05 with Triethyl amine: Methanol in the ratio 40: 60 v/v. An isocratic elution at a flow rate of 1.2 ml/ min at ambient temperature. The detection was carried out at 230 nm using waters UVVisible detector. The calibration curve was linear in the concentration range of 4–20mg/ ml (r2? 0.9999).The limit of detection and the limit of quantification were found to be 0.2515 mg/ml and 0.6623 mg/ml respectively. The amount of Telmisartan present in the formulation was found to be 99.95. The method was validated statistically using the SD, %RSD and SE and the values are found to be within the limits and the recovery studies were performed and the percentage recoveries was found to be 99.55± 0.7211 %. So, the proposed method was found to be simple, specific, linear, and rugged. Hence it can be used for applied for routine analysis of Telmisartan in the Pharmaceutical formulations.


Author(s): M. Lakshmi Surekha, G. Kumara Swamy, G. Lakshmi Ashwini

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
Flyer image

Abstracted/Indexed in

  • Chemical Abstracts Service (CAS)
  • Index Copernicus
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • MIAR
  • ResearchGate
  • University Grants Commission
  • Secret Search Engine Labs