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Abstract

Determination of Antibiotic resistance pattern of Biofilm producing Pathogenic Bacteria associated with UTI

The present study was aimed to ascertain the antimicrobial resistance of pathogenic bacteria associated with urinary tract infections (UTIs). Escherichia coli was found to be the most prevalent uropathogen (75.0%), followed by Klebsiella pneumoniae (12.5%), Pseudomonas spp. (8.33%) and Staphylococcus aureus (4.16%). Isolated bacteria (n=24) were characterized for their sensitivity to commonly prescribed antibiotics. Although Congo red binding assay indicated that all of the isolates (100%) were able to produce exopolysaccharide, only 70.83% of the isolated bacteria produced biofilm in tube adherence assays. Biofilm producing bacteria showed higher level of resistance against all of the antibiotics tested except to amikacin (30μg), meropenem (10μg) and piperacillintazobactam (100/10μg). Meropenem was found to be the most effective (87.5%) antibiotic and pathogens were mainly resistant to ciprofloxacin (62.5%). Multidrug resistance was observed for 91.6% of the isolates against  1 antibiotic of which 50% of the isolates showed resistance against  5 antibiotic


Author(s): Kabir Md. Shahidul, Akter Asma, Feroz Farahnaaz, Ahsan Sunjukta

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