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Abstract

Design, Development, and Evaluation of Oxcarbazepine Loaded Fast Dissolving Oral Film

The present study was aimed to develop a novel fast dissolving drug delivery system for an antiepileptic drug such as Oxcarbazepine. The fast dissolving films were prepared by solvent casting technique using water-soluble polymers such as hydroxyl propyl methylcellulose HPMC E-5 LV, E-50 LV. In this study PEG 400 was used as plasticizer and Mannitol was used as a sweetener. Concentration of water soluble polymers were optimized during preliminary studies. The prepared films were evaluated for thickness, weight uniformity, drug content, surface pH, folding endurance, tensile strength, percent elongation, in-vitro disintegration time, swelling index and in-vitro drug release studies. The results obtained showed no physical chemical incompatibility between the drug and the polymers. The prepared films were clear, transparent and smooth surface. D4 formulation showed maximum in-vitro drug release 94.35%, following first order kinetics (r2=0.9791).


Author(s):

Pooja RD and Sayyad FJ



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