Background: Diabetes mellitus is one of the most common metabolic disorders that causes microvascular and macro vascular complications. No study has ever examined the effect of vitamin C with glibenclamide on fasting (FBS) and postprandial blood sugar (PPBS) as well as glycosylated hemoglobin (HbA1c) in the treatment of type 2 diabetes mellitus (DM). Objective: The goal was to examine the effect of oral vitamin C with glibenclamide on FBS, PPBS in type 2 DM.. Methods: Ninety newly diagnosed Type 2 DM patients participated in a Randomized, open lable prospective study for 8-weeks. Newly diagnosed Type 2 DM patients were randomly divided into three groups .First group received glibenclamide 5mg orally,second group received glibenclamide 5mg with vitamin C 1g orally and third group received glibenclamide 5mg with vitamin C 2g orally .All groups received drugs daily for 8 weeks. Investigations like Fasting blood sugar (FBS), Post prandial blood sugar(PPBS) were measured before and after vitamin C consumption and the results were analyzed. Results: A significant decrease in PPBS level was seen in both the group supplemented with 1g and 2 g of vitamin C. However percentage of reduction in Postprandial blood sugar level is more in group receiving vitamin C 2g(15.4% ,P<0.001) than group receiving 1g (9.6% ,P<0.007). Conclusions: Our result showed that oral supplementation of vitamin C 2gm with glibenclamide reduces PPBS level. Hence, supplementation of vitamin C along with oral hypoglycemic drug helps in maintaining good glycaemic control in type 2 DM patients.
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