The present study is an attempt to find out whether medicinal plants maintain same kind of effectiveness or otherwise when extracted by different methods. Five medicinal plants were selected to screen their antimicrobial efficacy against four bacterial strains viz Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus vulgaris and two fungal strains Candida albicans and Aspergillus niger. Extraction was carried out by soxhlet and cold percolation method. There was much variation in the results. Compared to aqueous extract lipophilic extracts showed good result with both the methods.