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Abstract

ANTIDIABETIC ACTIVITY OF ETHANOLIC LEAF EXTRACT OF PANICUM MAXIMUM

Antidiabetic activities of ethanolic leaf extract of Panicum maximum used in folkloric management of diabetes.The ethanolic leaf extract of ethanolic leaf extract of Panicum maximum (47 ? 190mg/kg) was evaluated for antidiabetic activity in alloxan ? induced diabetic rats. The antidiabetic activity during acute and prolonged studies were investigated. Glibenclamide,10mg/kg, was used as positive control. Blood glucose level was measured at intervals by using glucometer.Treatment of alloxan diabetic rats with the ethanolic leaf extract of Panicum maximum (47 ? 190mg/kg) caused a significant (P<0.001) reductions in the Blood Glucose Level (BGL) of the diabetic rats both in acute and prolonged treatment (2 weeks). The activity of the extract during acute study was uncomparable to that of the reference drug, glibenclamide, but was only comparable to that of the reference drug during prolonged treatment at the highest dose(190mg/kg). The antidiabetic activity of the ethanolic leaf extract of Panicum maximum observed in this study confirms the folkloric use of these polyherbal remedies.


Author(s): BASSEY S. ANTIA , JUDE E. OKOKON, EMEM E. UMOH, JOHN A. UDOBANG

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