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Abstract

ANTICONVULSANT ACTIVITY OF ETHANOLIC EXTRACT OF FRUITS OF Terminalia chebula ON EXPERIMENTAL ANIMALS

Objective: To study the anticonvulsant activity of ethanolic extract of Terminalia chebula in albino mice.

Methods: The anticonvulsant activity of ethanolic extract of fruits of Terminalia chebula (200 and 500 mg/kg, p.o.) in mice was assessed by using maximum electroshock seizure (MES) test, Pentylenetetrazole (PTZ), and picrotoxin (PC) test.

Results: The ethanolic extract of Terminalia chebula significantly reduced the duration of seizures induced by maximal electroshock (MES). The ethanol extract in doses of 200 and 500 mg/kg conferred protection (17 and 50%, respectively) on the mice. The same doses also protected animals from pentylenetetrazole-induced tonic seizures and significantly delayed the onset of tonic seizures produced by picrotoxin.

Conclusion: The ethanolic extract of Terminalia chebula (EETC) possess anticonvulsant activity since it reduced the duration of seizures produced by maximal electroshock and delayed the latency of seizures produced by pentylenetetrazole and picrotoxin.


Author(s): Jiban Debnath, Uday Raj Sharma, Bimlesh Kumar, Nitesh Singh Chauhan

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