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Abstract

An Efficient method for Synthesis of Novel Iminothiazolo Pyrimidines and Plausible Antioxidant Potential

2-aminothiazole on treatment with bis(methylthio)methylene malononitrile in N, N'- dimethyl formamide (DMF) and anhydrous potassium carbonate afforded 6-Cyano-5-imino-7- (methylthio)-5H-thiazolo[3,2-a] pyrimidinewhich on further reacted with selected N–, O– and C– nucleophiles such as aryl and heteryl amines, substituted phenols and compounds with an active methylene group and synthesized 7-substituted derivatives of 6-Cyano-5-imino-5H-thiazolo [3,2- a] pyrimidine. These newly synthesized derivatives were further screened for their antioxidant potential.


Author(s): Sambhaji P. Vartale, Digambar B. Kadam, Nilesh K. Halikar and Mahesh M. Pund

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