Acne is one of the most common skin diseases affecting majority of the teens and reaching its pinnacle during adulthood. In certain severe cases, it mounts to pronounced skin deformity. This appears to adversely dampen the self esteem of the affected which can eventually lead to depression and even suicides. The disease invariably diminishes in twenties but in some cases, it might even persist in thirties, forties and beyond and there is no such definite way to predict its spell. Majority of females suffer from mild to moderate acne at some stage of life. Although the pathogenesis still stands unknown, but some of the probable reasons could be: increased sebum production, ductal keratinization, bacterial colonization of the pilosebaceus ducts and inflammation. Effective approach towards the treatment of acne primarily rests on thorough understanding of its pathogenesis. An indispensable factor demanding consideration for its treatment is personal and family history. Apart from genetic makeup, food habits also affect the severity of the disease. This review will lay emphasis on a brief disease pathogenesis underlined in the very disease and its impact on life.