The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing Aceclofenac as a model drug by using various proportion of polymers such as HPMC E5M and Eudragit RS 100. This was employed to enhance the bioavailability and therapeutic efficacy of the drug. The sustained release formulations of aceclofenac using hydrophobic and hydrophilic polymers were prepared by direct compression method. Optimization of formulation was done by studying effect of drug to polymer ratio on drug release. FT- IR studies indicated absence of any interaction between aceclofenac, polymer (Eudragit RS 100, HPMCE5M) and excipients. Five formulations were prepared and formulation A5 possessed good floating property with total floating time between 8-10 hours. The tablets were also evaluated for its hardness, friability and other In- vitro evaluation tests. All parameters complied with IP limits. Results of this study indicated that the combinations of hydrophilic polymers with hydrophobic polymers are suitable to optimize sustained release formulation of aceclofenac.
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