Injury to the nerves in animals are related to the pain models i.e., partial/total nerve transaction/ligation/chronic nerve constriction. Neuropathic pain can be a disabling side effect of cancer treatment. Chemotherapy induced peripheral neuropathy is toxic neuropathy that results from direct injury to peripheral nervous system. Experimental details of following behavior models observed in animals which are considered to indicate the pain are also included in the present review viz. a. autotomy (self-attack) b. hyperalgesia (withdrawal responses to moderate heat stimulus), c. allodynia (withdrawal in response to non-noxious tactile or cold stimuli). A range of drugs are available for symptomatic relief from neuropathic and inflammatory pain but these drugs have profuse side effects, most patients are still unsatisfied and many of them are refractory to existence medicines, this review also highlighted treatments available for neuropathic pain. Conservative drugs available for neuropathic pain are allied with life threatening side effects hence the role of drugs from natural source are the mainstay for its treatment, this review also hold the collection of studies reported on herbals and phytoconstituents in the neuropathic pain. Present review deals with basics of neuropathy, physiological and biological mechanism, animal models and treatment accessible for neuropathic pain.
Manoj K Aswar and Vijay R Patil
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