Introduction: Kidney transplantation provides a l i f e saving treatment for patients wi th End Stage Renal Disease (ESRD). But total success after transplantation is hugely dependent on proper course of immunosuppressive therapy. The rationale behind this study was to monitor, analyse, and evaluate the AEs and ADRs associated with immunosuppressive drugs and to document the pharmacotherapeutic actions taken for its management. Methodology: The study was Retrospective and medical data of all patients (as per inclusion/exclusion criteria) admitted during the Study Period was analysed. Results: A total of 95 patients were enrolled in the study and incidence rate of patient affected due to ADR was found to be 75.78 % and overall 352 AEs were documented. Causality and Severity assessment of ADRs were done which showed Probabale (47), and Moderate (47) respectively. Out of 84 ADRs, 80 ADRs were Not preventable. Furthermore significant relation was observed (p<0.005) among various factors, drugs and suspected ADRs. Conclusion: The results of this study show that immunosuppressive drugs may cause serious and frequent adverse effects. So, special monitoring and regular follow up of patients are required to minimise the risk and frequency of these adverse effects.