The synthesis of PLGA-Nanoparticles therapeutics capable of controlled loading and synchronized release of multiple therapeutic agents remains a difficult challenge in drug delivery and polymer chemistry. Herein, we report the synthesis of PLGA-Nanoparticles that carry accurate weight ratios of Amphotericin B and Doxorubicin. To our knowledge, this work provides the example of macrophage targeted therapy against visceral leishmaniasis by incorporating macrophage specific ligand-Lectin which specifically targets to the localized target sites. The highly convergent synthetic approach opens the door to new Nanoparticles based combination therapies for visceral leishmaniasis.
Prachi Sharma and Swati Gupta
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