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Abstract

1.International Journal of Drug Development & Research

The best new therapeutic entity in the world is of little value without an appropriate delivery system. The most important role of a drug delivery system is to get the drug ‘‘delivered’’ to the site of action in sufficient amount and the appropriate rate; however it must also meet a number of other essential criteria. These include physical and chemical stability, ability to be economically mass produced in a manner that assures the proper amount of drug in each and every dosage unit and in each batch produced and as far as possible patient acceptability. Gastro resistant tablet simply means that the drug is resistant to being broken down in the gastric system. Some medicines need to be absorbed in the intestines rather than the stomach, so they are given an enteric coating to help resist breakdown from stomach acid. “Delayed-release dosage forms are modified-release dosage forms showing a release of the active substance(s) that is delayed4. Enteric-coated dosage forms are designed to resist the acidic environment of the stomach and to disintegrate in the higher pH environment of the intestinal fluid. The sub coating and enteric coating of the core tablets was done. Proton pump inhibitors, H2 blockers, some NSAIDs, insulin delivery etc are suitable candidates for developing delayed release dosage forms. Proton pump inhibitors used in the treatment of GERD. Main aim of the current study is to develop stable delayed release tablet formulation for the drug belonging to proton pump inhibitor category.


Author(s): Patel Harshna, Solanki N S

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